Novince Laboratory

The Novince laboratory’s interests are centered in exploring novel immunomodulatory mechanisms regulating skeletogenesis. Current research is focused on studying the impact of the microbiome on osteoimmunology and skeletal development. Ongoing research has delineated that distinct microbiome communities (gut microbiota, oral microbiota) have unique immunomodulatory actions imparting catabolic effects on skeletal metabolism in health. Molecular/cellular research studies are focused on:

  • Commensal microbe – host immune response mechanisms.
  • Liver derived factors signaling to bone
  • Hematopoietic cell – bone cell interactions.
  • Osteoclast – osteoblast interactions.

The Novince laboratory’s development and application of cutting-edge osteoimmunology research techniques in the murine alveolar bone complex is providing opportunity for advancing knowledge about local vs. systemic host immune response effects on skeletal metabolism. The clinical relevance of the research is directed towards identifying noninvasive interventions in the microbiome, which could be applied to optimize pediatric skeletal development and minimize bone loss in the adult skeleton.